Anatomy
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Neuroanatomical Variability and Early Substance Use Initiation: Insights from the ABCD Study
Adolescence is a period of rapid brain development, making it a sensitive window for experiences that may shape long-term outcomes. A new study from the Adolescent Brain Cognitive Development (ABCD) project examined whether neuroanatomical variability is linked to early initiation of alcohol, nicotine, or cannabis. Drawing on baseline brain images taken before substance use began, the researchers found regionally specific differences in cortical thickness and surface area among early initiators. The findings highlight the complexity of adolescent neurodevelopment and point to the value of large-scale, longitudinal studies in clarifying how brain structure and behaviour unfold together.
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Progressive cortical thinning might identify children at risk of developing psychotic spectrum symptoms
Offspring of patients with schizophrenia or bipolar disorder have an increased risk of developing these conditions. However, our capacity to predict the long-term outcomes of these at-risk individuals is limited. Now, researchers have investigated whether longitudinal changes in brain structure differ in individuals at high familial risk who develop psychotic spectrum symptoms, compared to those who do not and to low-risk controls.
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Emotional abuse during childhood is linked with differences in brain structure
Delia Gheorghe and colleagues at the University of Oxford have harnessed data from the UK Biobank to delineate the relationship between adverse experiences and brain structure. The researchers accessed brain imaging data together with retrospective reports of childhood adversity and adulthood partner abuse from more than 6,000 adults (mean age, 62.1 years).
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Do brain function abnormalities lead to substance use, or vice versa?
New research has, for the first time, investigated the direction of links between brain function and substance use throughout adolescence. Jungmeen Kim-Spoon and colleagues studied 167 adolescents who were assessed annually for four years from 13-14 years old.
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Young people’s ‘neural fingerprints’ might permit a precision-medicine approach to depression
Precision medicine has been discussed in medical research since the late 1990’s. Only recently, however, has this concept aroused interest and inspired relevant research in psychiatry, particularly in adolescents.
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Cognitive flexibility in OCD: challenging the paradigm
Data from a new study by Nicole Wolff and colleagues suggest that cognitive flexibility can be better in children with obsessive-compulsive disorder (OCD) than typically developing controls.
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Cortical thickness can differentiate conduct disorder subtypes
A study by Graeme Fairchild and colleagues has used a neuroimaging approach to compare the structural organization (or “covariance”) of brain regions between youths with different subtypes of conduct disorder (CD) and healthy controls (HC).
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Accelerated cortical thinning correlates with early signs of depression
The brain undergoes structural changes as it develops over childhood, but whether abnormal structural changes are associated with emerging depressive symptoms in adolescence is unknown. Now, a longitudinal study that enrolled 205 participants aged 8-25 years without signs of depression has used magnetic resonance imaging (MRI) to monitor these brain changes over adolescence.
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