Family environment and polygenic risk in the bipolar high-risk context

Featured ACAMH Papers

Bringing you some selected Open Access journal papers from our portfolio; The Journal of Child Psychology and Psychiatry (JCPP), Child and Adolescent Mental Health journal (CAMH), and JCPP Advances.

Posted on 16 March 2023

‘Family environment and polygenic risk in the bipolar high-risk context’

Open Access paper from JCPP Advances

Background – The interaction of polygenic risk (PRS) and environmental effects on development of bipolar disorder (BD) is understudied, as are high-risk offspring perceptions of their family environment (FE). We tested the association of offspring-perceived FE in interaction with BD-PRS on liability for BD in offspring at high or low familial risk for BD.

Authors: Emma K. Stapp, Janice M. Fullerton, Rashelle J. Musci, Peter P. Zandi, Melvin G. McInnis, Philip B. Mitchell, Leslie A. Hulvershorn, Neera Ghaziuddin, Gloria Roberts, Alessandra G. Ferrera, John I. Nurnberger, Holly C. Wilcox

First published: 16 March 2023

https://doi.org/10.1002/jcv2.12143

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