‘Family environment and polygenic risk in the bipolar high-risk context’
Open Access paper from JCPP Advances
Background – The interaction of polygenic risk (PRS) and environmental effects on development of bipolar disorder (BD) is understudied, as are high-risk offspring perceptions of their family environment (FE). We tested the association of offspring-perceived FE in interaction with BD-PRS on liability for BD in offspring at high or low familial risk for BD.
Authors: Emma K. Stapp, Janice M. Fullerton, Rashelle J. Musci, Peter P. Zandi, Melvin G. McInnis, Philip B. Mitchell, Leslie A. Hulvershorn, Neera Ghaziuddin, Gloria Roberts, Alessandra G. Ferrera, John I. Nurnberger, Holly C. Wilcox
First published: 16 March 2023
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