Interplay of early negative life events, development of orbitofrontal cortical thickness and depression in young adulthood

‘Interplay of early negative life events, development of orbitofrontal cortical thickness and depression in young adulthood’

Open Access paper from JCPP Advances

Early negative life events (NLE) have long-lasting influences on neurodevelopment and psychopathology. Reduced orbitofrontal cortex (OFC) thickness was frequently associated with NLE and depressive symptoms. OFC thinning might mediate the effect of NLE on depressive symptoms, although few longitudinal studies exist. Using a complete longitudinal design with four time points, we examined whether NLE during childhood and early adolescence predict depressive symptoms in young adulthood through accelerated OFC thinning across adolescence.

Authors: Lea L. Backhausen, Jonas Granzow, Juliane H. Fröhner, Eric Artiges, Marie-Laure Paillère-Martinot, Hervé Lemaître, Fabio Sticca, Tobias Banaschewski, Sylvane Desrivières, Antoine Grigis, Andreas Heinz, Rüdiger Brühl, Dimitri Papadopoulos-Orfanos, Luise Poustka, Sarah Hohmann, Lauren Robinson, Henrik Walter, Jeanne Winterer, Gunter Schumann, Jean-Luc Martinot, Michael N. Smolka, Nora C. Vetter, the IMAGEN Consortium

Lea L. Backhausen and Jonas Granzow (first authors) and Jean-Luc Martinot and Michael N. Smolka (senior authors) have contributed equally.

First published: 06 December 2023

https://doi.org/10.1002/jcv2.12210

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