The interaction between polygenic risk and environmental influences: A direct test of the 3P model of insomnia in adolescents

‘The interaction between polygenic risk and environmental influences: A direct test of the 3P model of insomnia in adolescents’

Open Access paper from the JCPP

Stress is a universal phenomenon and one of the most common precipitants of insomnia. However, not everyone develops insomnia after experiencing a stressful life event. This study aims to test aspects of Spielman’s ‘3P model of insomnia’ (during adolescence) by exploring the extent to which: (a) insomnia symptoms are predicted by polygenic scores (PGS); (b) life events predict insomnia symptoms; (c) the interaction between PGS and life events contribute to the prediction of insomnia symptoms; (d) gene–environment interaction effects remain after controlling for sex.

Authors: Juan J. Madrid-Valero, Nicola L. Barclay, Alice M. Gregory

First published: 04 October 2024

https://doi.org/10.1111/jcpp.13895

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