Accelerated epigenetic ageing as a consequence of early environmental adversity
In this editorial, I discuss findings and implications of a hypothesis-generating study by Copeland and colleagues showing that early adverse events related to unpredictability as well as a cumulative score summarising environmental adversity in childhood and adolescence are linked to accelerated epigenetic ageing. The setting of this study is the longitudinal Great Smoky Mountains Study, a richly phenotyped longitudinal cohort with biological information. In my discussion, I focus on potential mechanisms behind the reported findings and opportunities for next steps, for example provided by the richness of data in the cohort used in this study.
We hope you enjoy the full editorial of this Issue, which is free on the Wiley Online Library.
Professor Barbara Franke is a Specialist Subject Editor of JCPP, her full profile can be found here.